The purpose of the study is to find out the relationship between T2DM and depression. The sample of the study comprised 652 patients of whom 348 were males and 304 were females and were taken from outpatient department (OPD) of Bangladesh Institute of Health Science (BIHS) Bashaboo, Dhaka and Bangladesh Institute of Research and Rehabilitation on Diabetes, Endocrine and Metabolic Disorder (BIRDEM), Shahbagh, Dhaka. Quantitative research methods were used in the study. The measures used in the study were: Depression Scale of Uddin & Rahman, Blood glucose was measured by glucometer called accu-check, in-depth interview and observational reports. The age range was between 20 and 80 years and their average age was 51±11 years. Their educational level was from illiteracy to doctorate degree. Duration of T2DM of the subjects were divided in three phases – (i) less than 1 years (14.9% males and 17.2% females), (ii) 1-10 years (17.6% males and 17.2% females) and (iii) above 10 years (20.9% males and 12.3% females). More than fifty percent were male and thirty eight percent females were married. In respect of occupation 41.1% female responded were housewives, 2.5% female responded were service holder, 0.5% female responded were business persons, 1.5% females were retired and other females 1.1%; whereas of male Ss 20.9% were jobholders, 14.3% were businessmen, 12.6% were retired persons and others were 5.7%. Seventy five percent of the sample showed minimal depression, 14.7% had mild depression, 5.8% had moderate depression and 4.4% showed severe depression.