Knee joint osteoarthritis (OA) is a common disease which causes serious joint inflammation and strictly limits patients’ usual mobility. Indeed a significant proportion of diabetic patients are victims of this knee joint OA. Concerning the effect of knee OA, present study was carried out, (i) to assess the proportion of osteoarthritis of knee joint among diabetic patients; and (ii) to investigate the effect of various risk factors (e.g. blood glucose level, duration of diabetes, effect of exercise) which are strictly associated with osteoarthritis. 150 diabetic patients (33.3% male and 60.7% female) of mid age were enrolled for this purpose. It has revealed from the present investigation that out of 150 diabetic patients 74% had osteoarthritis. On the other hand depending on the associated risk factors, percentage of knee joint osteoarthritis varies among the respondents. Nevertheless, it has been concluded from the present study that osteoarthritis is a distressing problem in people suffering from type 2 diabetes mellitus.