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DIU-JOURNAL OF ALLIED HEALTH SCIENCE

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Paper Title
In Vitro Comparative Quality Evaluation of Some Brands of Cephradine Capsules Available in Selected Community Pharmacies in Dhaka City

Authors

Sultana, Sharifa; Rahman, Md. Mominur; Islam, Fahadul; Parvin, Sumaiya

Abstract

Cephradine is a first-generation cephalosporin antibiotic used to treat infectious diseases caused by bacteria such as upper respiratory infections, ear infections, skin infections, and urinary tract infections. This project involved evaluating the quality of different brands of cephradine capsules available in the local market. Five different brands of marketed samples of cephradine capsules were collected from different retail pharmacy shops of Bangladesh. This study has been conducted by comparing various quality control parameters such as weight variation test, loss on drying, potency test, disintegration, dissolution test, and assay test from top, middle and lower grades pharmaceutical company of Bangladesh using standard techniques. The values were compared with the official specifications. The obtained result for weight variation is 0.58+0.71 to 2.13+3.01% and disintegration time were between 2.30+0.17 and 5.19+0.14 minutes. Loss on drying of all batches were in between 2.0933.17 and 2.52+2.84% and potency or assay result were 98.08+0.52 to 100.25+0.19%. Moreover, the release rate of different brands of cephradine was satisfactory within 45 minutes where the mean dissolution rate is 93.96+0.13 %. The obtained results of all parameters were complied with the pharmacopoeial limit. By evaluating these parameters, we can ensure the quality of the marketed cephradine capsules.

Keywords

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