Five generic ciprofloxacin HCl 500 mg tablets from different manufacturer have been evaluated to assess their bioequivalence using in vitro tests. Other general quality assessments of these tablets like assay, weigh variation, hardness, friability, disintegration and dissolution time were also determined and all these generic tablets passed compendial specifications. All the tablets contained ciprofloxacin from 90.51 ± 0.29 to 104.74 ± 1.53 of the labeled claim. The hardness of all generic tablets were within the range between 5.42 ± 0.25 to 6.76 ± 0.44 kg/cm2. Friability test is used to evaluate the tablet resistance to abrasion. The friability (%) of all generic tablets was within the range of 0.11 to 0.22. We observed that Ciprofloxacin-HCl tablets have a disintegration time from 3.11 ± 0.54 to 11.77 ± 0.75 minutes and more than 96% of drug undergo dissolution within 30 minutes which meet compendial specifications. These results indicated that all generic ciprofloxacin HCl tablets included in this investigation were good in quality and meet compendial specifications